In a significant leap for India’s biomedical research, scientists at Indian Institute of Technology Gandhinagar have developed an advanced injectable hydrogel that could transform early cancer detection and minimally invasive surgery.

The innovation, led by PhD scholar Harshil Dave, has already earned global recognition, winning the Vikram Sarabhai Young Scientist Award 2026—a major endorsement of its clinical promise.

From lab to life-saving application

The newly developed hydrogel represents a successful transition from laboratory research to a patented biomedical technology with real-world potential. Designed as a “smart” biomaterial, it can be injected as a liquid and then rapidly transform into a stable gel inside the body.

This property allows it to act as a temporary scaffold during medical procedures, particularly in treating colorectal polyps—abnormal tissue growths that can develop into cancer if left undetected.

Fixing a critical gap in cancer procedures

Current clinical practice relies on injecting saline beneath polyps to create a cushion for safe removal. However, saline is quickly absorbed, often forcing doctors to repeat injections, increasing both time and procedural risk.

The IIT Gandhinagar hydrogel addresses this limitation decisively. Once injected through an endoscopic catheter, it forms a durable cushion that improves visibility and stability during surgery. This reduces the risk of bleeding and tissue damage, making procedures safer and more efficient.

Dr Mukesh Dhanka highlighted that such biomaterials can significantly enhance procedural safety while addressing key challenges in cancer prevention and wound healing.

Powered by plant-based innovation

Developed using a plant-derived molecule, diglycerolmonostearate, the hydrogel exhibits “shear-thinning” behaviour—flowing easily during injection but solidifying once in place. This dual nature makes it ideal for precision-driven, minimally invasive interventions.

Beyond detection: Healing and regeneration

The implications extend far beyond cancer detection. The hydrogel creates a protective, moisture-rich environment that promotes tissue regeneration and wound healing. Its antibacterial, antioxidant, and anti-inflammatory properties further strengthen its clinical potential.

Researchers believe such multifunctional biomaterials could redefine approaches to early cancer intervention, safer surgeries, and even targeted drug delivery systems.

Recognition fuels next phase

Reflecting on the achievement, Dave said the recognition reinforces his commitment to translating biomaterial innovation into technologies that directly improve patient outcomes.

With promising lab results already in place, the next phase will focus on validation studies and eventual human trials—critical steps toward real-world clinical adoption.

A glimpse into the future of surgery

As the research progresses, injectable hydrogels like this could fundamentally reshape minimally invasive procedures—reducing complications, improving recovery, and strengthening early cancer prevention strategies worldwide.

The breakthrough also underscores IIT Gandhinagar’s growing stature as a hub of interdisciplinary innovation, where science, engineering, and healthcare converge to tackle some of medicine’s most pressing challenges.